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INCLEN
Knowledge Management Plus in MDR-TB – The Structure and
Process involved in the Development of Novel Clinical Practice
Guidelines (CPG) for MDR-TB [No
abstract available]
Ghosh CS, Ravindran P, Tony Dans Antonio, Joshi M
Dept.of Respiratory Medicine, Medical College, Trivandrum
Drug
Resistance of Mycobacterium Tuberculosis to Quinolones – A
Prospective Clinical Study
Sreejith MO, Abdul Nazar, Ravindran C, James P.T,
Remeshchandra Babu K.M.
Institute of Chest Diseases, Medical College, Calicut.
Abstract:
Study
objectives: To study the susceptibility of Mycobacterium tuberculosis
to Ciprofloxacin and Ofloxacin in sputum positive cases of pulmonary
tuberculosis, and also to study the initial drug resistance of
Mycobacterium tuberculosis to Quinolones among patients treated with
first line antituberculosis drugs.
Design and
setting: Prospective clinical study, conducted in Institute of Chest
Diseases, Medical College, Calicut.
Participants:
Sputum positive pulmonary tuberculosis cases, without history of prior
treatment with Ciprofloxacin and/or Ofloxacin as antituberculosis
drugs
Study protocol:
All patients were subjected to detailed history, clinical examination
and needed investigations including BACTEC culture and drug
susceptibility testing.
Results: Of 36
patients studied, five (13.89%) patients were sensitive to all 5 first
line drugs and 16 (44.44%) patients were sensitive all 5 second line
drugs. MDR pattern was found in 26 (72.22%) patients. Resistance to
Ciprofloxacin as found in 4 (11.11%) patients and 2 (5.56%) patients
were resistant to Ofloxacin.
Conclusion: Resistance of
Mycobacterium tuberculosis to Ciprofloxacin and Ofloxacin, in patients
who have not received such drugs in there antituberculosis regime, is
likely to be due to wide and irrational use of Fluoroquinolones in the
treatment of infection other than tuberculosis.
Study
of Personality Dimensions and Life Events of
Bronchial Asthma Patients
Aravindan
PP, Razeena Padman MS,
School of Behavioural Sciences, Mahatma Gandhi
University, Kottayam.
Abstract:
Objective:
1)
To study whether people with bronchial asthma and
people without bronchial asthma differ in personality
2)
To study whether people with bronchial asthma and
people without bronchial asthma differ in life events
3)
To study whether male patients with bronchial
asthma and female patients with bronchial asthma differ in personality
To study
whether male patients with bronchial asthma and female patients with
bronchial asthma differ in life events.
Design
:
Case Control Study
Setting
:
Secondary and Tertiary care setting
Participants:
128 patients diagnosed as bronchial asthma as cases and 128 persons
not suffering from bronchial asthma as controls.
Main outcome measure : Personality dimensions as Extraversion /
Introversion, Neuroticism / Stability and Life events score were
assessed in 128 patients with bronchial asthma and compared with 128
persons without bronchial asthma and also compared between male and
female patients with bronchial asthma.
Results:
The first objective of the study mainly aims at finding whether there
is any significant difference between asthmatic and non asthmatic
individuals in personality dimensions. Personality dimensions studied
were extraversion / introversion and neuroticism/stability. From the
mean scores it can be seen that the non-asthmatic group has a high
score in extraversion than the asthmatic group. From the Table.1, it
is obvious that the mean score of asthmatic group is 11.7031 and that
of the non-asthmatic group is 12.7188. This shows non asthmatic
individuals are more extraverted than the asthmatics. Bronchial asthma
patients are more introverts. From the Table.1, it is seen than there
is highly significant difference between experimental and control
group in terms of personality dimension of neuroticism. There is high
mean score of 14.5078 for the asthmatic group than the mean score of
the non-asthmatic group 9.6875. The ‘t’ test value shows
significance at 1% level of neuroticism. It clearly proves that
bronchial asthma patients are more in neuroticism dimension than the
non-asthmatic group who are in the stability dimension.
Table-2 shows significant difference between male and female
patients in personality dimensions of extraversion and neuroticism.
The mean for male being 12.9018 and for females the mean being 11.6736
for extraversion; and the ‘t’ value is 2.565 which is found
significant at 1% level. Also the mean for male being 10.6607 and for
female the mean being 13.2153 for neuroticism and the ‘t’ value is
-3.542 which is found significant at 1% level. Hence there is
significant difference between male and female asthmatic patients in
extraversion and neuroticism.
From Table.1, it can be seen that the ‘t’ value shows
highly significant difference in terms of stressful life events in the
experimental group than the score in the control group. The average
mean scores obtained for the experimental group is 29.0313 and the
control group is 19.8359. It is clear from the mean score that the
asthmatic patients have experienced more number of life events when
compared to the non asthmatic individuals.
From Table 3, it can be seen that there is no significant
difference between male and female asthmatic patients in life events.
It is obvious from the table that the mean for males are 24.1161 and
for females it is 24.6806. The ‘t’ value being -349. There is no
significant difference between male and female asthmatic patients in
relation to life events.
Conclusion:
Bronchial
asthma patients are less extraverts than normal subjects. They are
more in introversion dimension. Bronchial asthma patients are more in
the neuroticism dimension than normal subjects. Stressful life events
are more in bronchial asthma patients than normal individuals.
Significant difference was found between male and female bronchial
asthma patients for extraversion and neuroticism. Male patients with
bronchial asthma are more extraverts than female patients. Female
patients with bronchial asthma are more in neuroticism scale than male
patients with bronchial asthma. Stressful live events do not show
variation with sex.
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